Assessment of -243A>G Polymorphism of Glutamate Decarboxylase 2 Gene in Obese Patients
Nouran Mahmoud Bahig Mustafa El-Mihi;
Abstract
besity is a common multifactorial public health problem.
The worldwide prevalence of obesity nearly tripled
O
between 1975 and 2016. The estimated prevalence of
overweight and obesity in Egypt is 61–70% of the adult
population. It is also considered as one of the top contributors
to mortality among Egyptians.
GAD2 gene is one of the studied genes that is suggested
to be associated with obesity. It encodes for the 65-kDa isoform
of the enzyme GAD2 which catalyzes the formation of GABA
from glutamic acid. The GABA in the hypothalamus functions
together with NPY in the paraventricular nucleus to stimulate
food intake. In addition, GABA serves as a functional regulator
of the pancreatic hormonal release.
Some researchers hypothesize that single nucleotide
polymorphisms
(SNPs
) in GAD2 gene may enhance the over
expression of the GAD2 resulting in overeating and obesity.
One of the suggested SNPs in GAD2 gene is the -243A>G
polymorphism
(rs2236418
) where the adenine
(A
) nucleotide is
substituted by the guanine
(G
) nucleotide at the 243
rd
position
in the non-coding 5’prime promoter region of the GAD2 gene.
The worldwide prevalence of obesity nearly tripled
O
between 1975 and 2016. The estimated prevalence of
overweight and obesity in Egypt is 61–70% of the adult
population. It is also considered as one of the top contributors
to mortality among Egyptians.
GAD2 gene is one of the studied genes that is suggested
to be associated with obesity. It encodes for the 65-kDa isoform
of the enzyme GAD2 which catalyzes the formation of GABA
from glutamic acid. The GABA in the hypothalamus functions
together with NPY in the paraventricular nucleus to stimulate
food intake. In addition, GABA serves as a functional regulator
of the pancreatic hormonal release.
Some researchers hypothesize that single nucleotide
polymorphisms
(SNPs
) in GAD2 gene may enhance the over
expression of the GAD2 resulting in overeating and obesity.
One of the suggested SNPs in GAD2 gene is the -243A>G
polymorphism
(rs2236418
) where the adenine
(A
) nucleotide is
substituted by the guanine
(G
) nucleotide at the 243
rd
position
in the non-coding 5’prime promoter region of the GAD2 gene.
Other data
| Title | Assessment of -243A>G Polymorphism of Glutamate Decarboxylase 2 Gene in Obese Patients | Other Titles | تقييم المتغير الجيني لإنزيم حمض الجلوتامات ديكاربوكسيلاز٢ (-243A>G) في مرضى السمنة | Authors | Nouran Mahmoud Bahig Mustafa El-Mihi | Issue Date | 2019 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| CC3702.pdf | 925.29 kB | Adobe PDF | View/Open |
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