Nitric oxide is negatively correlated to pain during acute inflammation
Hamza, May; Wang, Xiao-Min; Wu, Tongtong; Brahim, Jaime S; Rowan, Janet S; Dionne, Raymond A;
Abstract
The role that nitric oxide (NO) plays in modulating pain in the periphery is unclear. We show here, the results of two independent clinical studies (microdialysis and gene expression studies) and a pilot dose finding study (glyceryl trinitrate study), to study the role of NO in the early phase of acute inflammatory pain following oral surgery. The effect of ketorolac on NO production and nitric oxide synthase (NOS) gene expression was also studied.
Other data
| Title | Nitric oxide is negatively correlated to pain during acute inflammation | Authors | Hamza, May ; Wang, Xiao-Min; Wu, Tongtong; Brahim, Jaime S; Rowan, Janet S; Dionne, Raymond A | Keywords | ASPIRIN-LIKE DRUGS;PROSTAGLANDIN E-2 RELEASE;INDUCED THERMAL HYPERALGESIA;CONTROLLED CLINICAL-TRIAL;DOUBLE-BLIND;INOS-DEFICIENT;SYNTHASE;MODEL;GENE-EXPRESSION;LOW-BACK-PAIN | Issue Date | 15-Sep-2010 | Publisher | SAGE PUBLICATIONS INC | Journal | Molecular pain | ISSN | 1744-8069 1744-8069 |
DOI | 10.1186/1744-8069-6-55 | PubMed ID | 20843331 | Scopus ID | 2-s2.0-77956506638 | Web of science ID | WOS:000282487800001 |
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| File | Description | Size | Format | Existing users please Login |
|---|---|---|---|---|
| Molecular pain 2.pdf | 741.98 kB | Adobe PDF | Request a copy |
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