Cytotoxic eudesmane sesquiterpenes from Crepis sancta
Ebada, Sherif; El-Kashef, DH; Müller, W.E.G.; Proksch P.;
Abstract
Chemical exploration of Crepis sancta (L.) Bornm. (Asteraceae) aerial parts afforded two new eudesmane sesquiterpenes (1 and 2) together with three known congeners (3-5) and two known methylated flavonoids (6 and 7). Structure elucidation of the new compounds was unambiguously performed based on HRESIMS, 1D and 2D NMR spectroscopic analyses. All isolated compounds were subjected to an in vitro cytotoxicity assay against mouse lymphoma (L5178Y) cells, revealing moderate activities with IC50 ranging from 7.9 to 21.0 μM.
Other data
| Title | Cytotoxic eudesmane sesquiterpenes from Crepis sancta | Authors | Ebada, Sherif ; El-Kashef, DH; Müller, W.E.G.; Proksch P. | Keywords | Crepis sancta (L.) Bornm; Asteraceae; Eudesmane sesquiterpene; Antiproliferative activity; AERIAL PARTS; ACID; BIOSYNTHESIS; DERIVATIVES; GLUCOSIDE | Issue Date | 2019 | Publisher | ELSEVIER | Journal | PHYTOCHEMISTRY LETTERS | ISSN | 1874-3900 | DOI | 10.1016/j.phytol.2019.07.007 | Scopus ID | 2-s2.0-85069546131 | Web of science ID | WOS:000488085100010 |
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