Antioxidant and anti-inflammatory effects of acrocarpus fraxinifolius on hyperglycemia, hyperlipidemia and liver/kidney dysfunctions against alloxan induced type 1 diabetes in rats

Abstract

Many factors such as oxidative stress and pro-inflammatory cytokines cause β-cell dysfunction and death. The aim of this study was to investigate antioxidant and anti-inflammatory effects of Acrocarpus fraxinifolius (A. fraxinifolius) on hyperglycemia, hyperlipidemia and liver/kidney dysfunctions against alloxan induced Type 1 diabetes in rats. Thirty six male white albino rats were divided into 6 groups: Control group, diabetic group and two prophylactic group with two different doses and two therapeutic group with two different doses (250 or 500 mg/kg b.w; for 28 consecutive days). Diabetes was induced by i.p. injection of 75 mg/kg b.walloxan monohydrate for 5 consecutive days. In this study showed that A. fraxinifolius extract [especially prophylactic treatment] significantly suppressed diabetic complications in alloxan-induced diabetes in rat model by alleviating body weight loss, hyperglycemia, hypo-insulinemia and dyslipidemia through activating the antioxidant defense system, decreasing of oxidative/nitrosative stress as well as lipid peroxidation, and increasing/decreasing the production of anti-inflammatory/pro-inflammatory cytokines, respectively. The percentage of disease recovery was 15.00 ± 5.472 % in high dose A. fraxinifolius of prophylactic treatment compared with alloxan only group 73.70 ± 22.09 % (p < 0.05).The data confirmed property of A. fraxinifolius as an antioxidant and anti-inflammatory that ameliorates oxidative/nitrosative stress and revealed that it is efficiently improves diabetic complication in alloxan-induced diabetic rats.