Synthesis of bactericides via carbon nucleophilic addition on 1,3- diarylprop-2-enones as Michael acceptors
Salem, Mounir A.I.; Hassan M. F. Madkour; Soliman, El Sayed A.; Mahmoud, Naglaa F.H.;
Abstract
Treatment of α,β-unsaturated ketones (I) with malononitrile in presence of ammonium acetate afforded 2-amino-4,6-diarylnicotinonitriles (II) which reacted with aq. alc. KOH, CS2 (pyridine), CS2 (EtOH/NaOH), phenyl isothiocyanate and guanidine hydrochloride to yield the corresponding heterocyclic products (III-VII) respectively. When I was allowed to react with cyanoacetanilide, ethyl chloroacetate, benzyl cyanide, 4- chlorobenzaldehyde and potassium cyanide, it gave the Michael adducts (VIII- XII). Fusion of XIb with hydrazine hydrate afforded XIII whereas treatment of XIb with hydrazine hydrate and/or hydroxylamine hydrochloride gave XIVa and b respectively. The evaluation of the minimal inhibitory concentration (MIC) of some of the synthesized compounds was carried out.
Other data
| Title | Synthesis of bactericides via carbon nucleophilic addition on 1,3- diarylprop-2-enones as Michael acceptors | Authors | Salem, Mounir A.I.; Hassan M. F. Madkour ; Soliman, El Sayed A.; Mahmoud, Naglaa F.H. | Issue Date | 1-May-2000 | Journal | Heterocycles | Volume | 53 | Issue | 5 | Start page | 1129 | End page | 1143 | ISSN | 03855414 | DOI | 10.3987/com-98-8232 | Scopus ID | 2-s2.0-0034193695 |
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