Synthesis and Chemoprophylactic Effect of Novel Coumarin Derivatives.
Nofal, Z. M.; El-Zahar, M. I.; Salem, M. A.I.; Hassan M. F. Madkour; El-Karim, S. S.Abd;
Abstract
A SERIES of coumarin derivatives carrying different biologically active side chains and heterocyclic substituents were synthesized from 8-acetyl-4-methyl-7-hydroxycoumarin. Among these side chains are alkylamino, semicarbazono- and N4-substituted thiosemicarba-zonoethyl, 1-hydrazonoethyl and substituted 1-hydroximinoethyl groups, while heterocyclic substituents were drived fom pyran, oxadiazole, thiadiazole and thiazolidinone rings. Also, some derivatives of pyrano[2,3-h]chromen-9-carbaldehyde were synthesized. Some of these new products were studied for their chemoprophylactic effect in Schistosoma mansoni infected mice.
Other data
| Title | Synthesis and Chemoprophylactic Effect of Novel Coumarin Derivatives. | Authors | Nofal, Z. M.; El-Zahar, M. I.; Salem, M. A.I.; Hassan M. F. Madkour ; El-Karim, S. S.Abd | Keywords | 2,10-Dioxo-pyrano [2, 3- h] chromen - 9 - carboxaldehyde;8-Acetyl-7-hydroxy-4-methylcoumarin;Carbo-hydrazide;Chromopro-phylaxis;Schistosoma mansoni;Thiazole;Thiazolidinone;Thiosemicarbazides | Issue Date | 1-Dec-2005 | Journal | Egyptian Journal of Chemistry | ISSN | 04492285 | Scopus ID | 2-s2.0-33748282145 |
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