Effect of atorvastatin on single oral pharmacokinetics and safety of daclatasvir in rats: Emphasis on P-glycoprotein and cytochrome P450
Elbadawy, Heba A; Sara Abdel Moneim Wahdan; El-Demerdash, Ebtehal;
Abstract
This study was aimed to investigate the effect of atorvastatin on daclatasvir oral pharmacokinetics and safety and assess the possible underlining mechanisms through targeting P-glycoprotein (P-gp) and cytochrome P450 (CYP3A4).
Other data
| Title | Effect of atorvastatin on single oral pharmacokinetics and safety of daclatasvir in rats: Emphasis on P-glycoprotein and cytochrome P450 | Authors | Elbadawy, Heba A; Sara Abdel Moneim Wahdan ; El-Demerdash, Ebtehal | Keywords | Atorvastatin;CYP3A4;Daclatasvir;P-glycoprotein;pharmacokinetics interaction;toxicity | Issue Date | 4-Apr-2022 | Journal | Current drug metabolism | ISSN | 13892002 | DOI | 10.2174/1389200223666220404134524 | PubMed ID | 35379125 |
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