Synthesis of novel pyrazole derivatives as Antineoplastic Agent

Abstract

Anticancer evaluation of pyrazole 2 and Schiff base 5 is reported. Synthesis of some important heterocyclic compounds via 2,3-diaryloxirane-2,3-dicarbonitrile 1, pyrazole 2, and Schiff base 5 with different nitrogen nucleophiles afforded new routes for synthesized fused heterocyclic derivatives. These compounds can be used as a key starting materials to synthesize some important imidazolo-[4,5-c]pyrazole, pyrazolo[3,4-e]1,2,4-triaging, imidazolo[3,2-b]pyrazole, and pyrazolo-pyrazine, as anticancer reagents showed good results at optimum conditions (400–500 ppm), particularly the bridge head nitrogen compounds, and could be used to improve them. Electromeric effect of the halogen atom in the aryl moieties can be controlled upon the rate of reaction and the yield of the product. The structure of the synthesized new compounds would be characterized by elemental and spectral data.