A comparative study of metal -catalyzed three-component synthesis of α- aminophosphonate
Marwa M. Abdeen; Mohamed A. Hamed,; Abdel Aleem Hassan Abdel Aleem; Nassar, Ibrahim F.; brahim E.T. El-Sayed;
Abstract
Different metal catalysts have been tested for the one-pot transformation of carbonyl compounds, amines and phosphites to α-aminophosphonates. The influence of catalyst type, amount, solvent and the substrate electronic factor have been investigated. The results revealed that the carbonyl compounds could be smoothly converted into α-aminophosphonates at room temperature in good to excellent yields, with or without solvent in a reasonable reaction time. These results suggested that among others, lithium perchlorate and metal triflates were proven to be effective catalysts in 10 moles % catalysts. Polar aprotic solvents proved to be the best for the synthesis of α-aminophosphonates. The synthesized compounds' structure characterizations were elucidated by different spectroscopic tools and showed results consistent with the expected structures.
Other data
| Title | A comparative study of metal -catalyzed three-component synthesis of α- aminophosphonate | Authors | Marwa M. Abdeen; Mohamed A. Hamed,; Abdel Aleem Hassan Abdel Aleem; Nassar, Ibrahim F. ; brahim E.T. El-Sayed | Keywords | Carbonyl compounds Amines Phosphite Catalyst α-Aminophosphonates | Issue Date | 1-May-2021 | Publisher | GrowingScience | Journal | Current Chemistry Letters | metadata.dc.identifier.artno | 10.5267/j.ccl.2021.1.006 | Volume | 10 | Issue | 3 | Start page | 221 | End page | 234 |
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| ccl_2021_5 (1).pdf | paper | 531.06 kB | Adobe PDF | Request a copy |
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