Detection of MicroRNA levels in amyotrophic lateral sclerosis patients

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. It is one of the motor neuron diseases in which motor neurons (MNs) are selectively lost. This progressive loss of MNs results in muscle denervation and atrophy, leading usually to death within few years. There is no definitive diagnostic test for ALS; diagnosis is based on clinical findings, electromyography results and exclusion of mimics.