Assessment of low-cost surgical metallic clip placement for tumour localization in BIRDAS VI breast cancer patients undergoing neoadjuvant chemotherapy"

Abstract

Breast malignancy is one of commonest tumor affecting women, representing 31% of overall tumours affecting the female population. The incidence and mortality rate of breast cancer are directly proportional to the female age.

The increase in breast cancer incidence is accompanied by an increase in the clinician and researchers concerns in the improvement of diagnostic and therapeutic tools.

Neoadjuvant chemotherapy (NAC) is now considered the standard of care for breast cancer patients with operable or inoperable tumours leading to decreasing the mortality incidence, changing the surgical approach as the use of breast conservative surgery (BCS) or lumpectomy instead of (for example) modified radical mastectomy (MRM), and converts the inoperable lesions into operable ones, lessening the unfavorable postoperative complications and improving cosmetic outcomes. It also assists in early detection of tumor response to therapy and tumour biology of breast cancers.

Multiple studies demonstrated the high clinical response rate of the primary breast lesion to the NAC and in some patients complete clinical, radiological and pathological response can be attained following NAC, that may hinder proper localization of any residual tissue by the radiologists or the surgeon .