A Retrospective Analysis of Epidemiological features and Clinical Outcomes of Patients with Malignant Pleural Mesothelioma Treated in Ain Shams Clinical Oncology Department in the Period from 2017 to 2020

Abstract

alignant pleural mesothelioma is a rare tumor of pleural membrane of lungs and comprise a wide array of varying biological aggressiveness. Data regarding the epidemiology of mesotheliomas is presented in the literature and vary according to many factors and hence consequently affect the outcome. We aimed at retrospectively analysing clinico- epidemiological characteristics and survival outcomes of adult malignant pleural mesothelioma patients presented to clinical oncology department in Ain Shams University hospital (ASU) in Cairo, Egypt in the period from 2017 till 2020. Convenient sampling of 120 patients with adult malignant pleural mesothelioma was done. The primary objective was to analyze the epidemiological and demographic data and to assess progression free survival (PFS) after each treatment modality in the study population. Secondary objectives included overall survival its correlation with various factors as well as treatment toxicities. One hundred twenty participants were included, with a median age of 56.5 years, with a male to female ratio of 1:1.14. Incidence was more common among Shubra Al Khaima and Helwan residents accounting for 35.8% and 15% of the cases respectively. Epithelioid mesothelioma was the most common pathological subtype representing 86.6% of the cases. Most of the cases were stage I at presentation.