Effect of Narrow Band Ultraviolet B Therapy on Tissue Levels of Interleukin-33 in Egyptian Vitiligo Patients

Abstract

Background: Vitiligo is an acquired pigmentary disorder of unknown etiology, affecting approximately 1 % of the world population, without predilection for race or sex. It is characterized by white macules and patches, whose size increases over time, due to the loss of melanocytes.

Aim and Objectives: The aim of the work was to study the influence of the NB-UVB radiation therapy on tissue level of IL-33 in patients with vitiligo

Subjects and methods: This is a prospective cohort study which was carried out on 10 patients diagnosed as having non -segmental vitiligo stable for at least 6 months duration. All patients were selected from the dermatology outpatient clinic of vitiligo, Ain- Shams University Hospitals.

Results: There was a statistical significant difference in VASI score before and after treatment with NB-UVB (p value 0.008), NB-UVB has no effect on tissue expression of IL-33 regarding percentage of cells (p value 0.102), staining intensity (p value 0.375) and the overall score (0.106).

Conclusion: NB-UVB is an effective treatment in patients with vitiligo. VASI score was decreased significantly at the end of NB- UVB treatment. NB-UVB has no effect on tissue expression of IL- 33 regarding percentage of cells, staining intensity and the overall score.