Evaluation of the Antifungal Activities of Some Essential Oils Against Some Clinically Important Filamentous Fungi
Ghada Khallaf Fathallah Khallaf;
Abstract
Abstract
Invasive fungal infections (IFIs) have emerged in the last three decades as an important cause of human disease. These infections are treated mostly with triazole as fluconazole, itraconazole and voriconazole but some serious adverse reactions have been reported in many studies. In vitro activities of 12 essential oils were evaluated against 6 clinically important fungal strains. Thyme oil was the most effective essential oil against all the tested fungal strains and Aspergillus flavus was the most susceptible with inhibition zone diameter and (MIC) Minimum inhibitory concentration values of 39 mm and 0.25 µg/ml, respectively. Active constitutes of thyme oil were analyzed by using the Gas-chromatography/Mass (GC/Mass) and then extracted by Thin Layer Chromatography (TLC). Thymol was the most active component against Aspergillus flavus with inhibition zone diameter and MIC values of 44 mm and 0.125 µg/ml, respectively. Thymol inhibitory activity against Aspergillus flavus was confirmed using Transmission electron microscope.
Invasive fungal infections (IFIs) have emerged in the last three decades as an important cause of human disease. These infections are treated mostly with triazole as fluconazole, itraconazole and voriconazole but some serious adverse reactions have been reported in many studies. In vitro activities of 12 essential oils were evaluated against 6 clinically important fungal strains. Thyme oil was the most effective essential oil against all the tested fungal strains and Aspergillus flavus was the most susceptible with inhibition zone diameter and (MIC) Minimum inhibitory concentration values of 39 mm and 0.25 µg/ml, respectively. Active constitutes of thyme oil were analyzed by using the Gas-chromatography/Mass (GC/Mass) and then extracted by Thin Layer Chromatography (TLC). Thymol was the most active component against Aspergillus flavus with inhibition zone diameter and MIC values of 44 mm and 0.125 µg/ml, respectively. Thymol inhibitory activity against Aspergillus flavus was confirmed using Transmission electron microscope.
Other data
| Title | Evaluation of the Antifungal Activities of Some Essential Oils Against Some Clinically Important Filamentous Fungi | Other Titles | تقييم الأنشطة المضادة للفطريات لبعض الزيوت الاساسية ضد بعض الفطريات الخيطية ذات الأهمية الطبية | Authors | Ghada Khallaf Fathallah Khallaf | Issue Date | 2022 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| BB13762.pdf | 925.96 kB | Adobe PDF | View/Open |
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