Assessment of aerosolized Colistin and Gentamicin in mechanically ventilated patient

Abstract

arenteral administration of antibiotics is often ineffective in treating VAP, due to difficulties associated with achieving effective antibiotic concentrations at the site of infection within the lungs. Many antibiotics exhibit limited penetration into lung secretions following intravenous administration. As well, parenteral antibiotics often achieve poor perfusion into consolidated regions of the lungs. Sub-therapeutic concentrations of antibiotics may lead to a longer duration of treatment, and ultimately result in bacterial resistance to antibiotics. Inhaled antibiotics dramatically improve targeting of drug to the site of respiratory infections, while simultaneously minimizing systemic exposure and associated toxicity. The high local concentrations of antibiotic may enable more effective treatment of multi-drug resistant pathogens. The current study was conducted as a randomized control trial (RCT) in RICU of Abbasia chest hospital after ethical approval from both hospital and Ain Shams university ethical committee, to assess the efficacy of aerosolized antibiotics (Colistin and Gentamicin) in improving the mechanically ventilated patient as adjunctive to intravenous systemic antibiotics, and included 30 mechanically ventilated patients who fulfilled the eligible criteria and were chosen by randomized methods.