SYNTHETIC STUDIES AND REACTIONS OF SOME HETEROCYCLIC COMPOUNDS

Abstract

Pyrazolone and isatin compounds show a great importance due to their wide applications for industrial uses and biological fields. In this work, we aimed to synthesis some new heterocyclic compounds from pyrazolone and isatin series hopping that such new compounds will have certain biological effects or other applied uses. The thesis is divided into three chapters : - CHAPTER I: This chapter includes the literature survey on the reactions of isatin with pyrazolones, the synthesis of isatylidenes and the synthesis and reactions of pyrazolone blue.. CHAPTER II : - This chapter is concerned with the discussion of the experimental results obtained in this work. The starting material, pyrazolidineindolone derivative (78) was synthesised by condensing of 2H-1-phenylpyrazolidine- 3,5-dione (77) with isatin (2) in absolute ethanol. The reaction of pyrazolidineindolone derivative (78) with active methylenes. was studied. Thus treating of •pyrazolidineindolone derivative (78) with malononitrile gave 6-amino-5-cyano-2H-3-oxo-1-phenylspiro- [pyrazolo-(3,4-b)-pyran-4(4H),31(3H)-indoi]2'(11H)-one (81) as shown in chart (1).