Role of platelet rich plasma in managementof knee osteoarthritis;SystematicReviewand meta analysis

Abstract

The aim of the current review and Meta analysis is to explain the role of platelet rich plasma (PRP) in the management of knee osteoarthritis and compares its effect with other treatments used, by analyzing studies that included the comparison between effect of PRP and others. Inflammation in the knee joint present within the synovium was proved to be responsible for cartilage degeneration and development of knee osteoarthritis by the action of inflammatory mediators and cytokines present within the synovium, therefore presence of pro-inflammatory cytokines and the presence of a specific dose of platelets and growth factors in autologous platelet rich plasma has been shown to enhance tissue repair and reduce tissue inflammation Platelet-rich plasma (PRP) is a portion of whole blood with an elevated platelet concentration. PRP works through the degranulation of α granules in platelets, which in turn causes the release of growth factors. These growth factors include transforming growth factor beta (TGF-β), basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 and insulin-like growth factor-2 (IGF-1 and IGF-2) and connective tissue growth factor (CTGF).