Role of Diosmin-Hesperidin Combination (Daflon® Tablets Servier) in Treatment of Vasomotor Rhinitis A Meta-Analysis

Abstract

Rhinitis is defined as inflammation of the membranes lining the nose, characterized by nasal symptoms including itching, rhinorrhea and nasal congestion. Rhinitis represents a global health problem affecting between 10% and 25% of the world population. Objectives: To review the efficacy of combination of diosmin and hesperidin effect on vasomotor rhinitis symptoms versus intranasal steroids only on improvement scale in improvement of symptoms of Vasomotor Rhinits. Patients and Methods: A meta-analysis examining the use of Diosmin hesperidin combination in treatment of vasomotor rhinitis in combination or in comparison with intranasal sterids. As our study involved examining only the existing peer-reviewed literature, Institutional Review Board approval was deemed unnecessary. Comparison between group A and group B regarding percentage of recovery: Group A: received Diosmin, Hesperidin combination (Daflon 500 mg tablets), group B: received intranasal steroids inhalers. Results: Our study proved that Diosmin Hesperidin combination has a venotonic action on the nasal mucosa that decrease its secretions and decreases nasal obstruction and rhinorrhea and sneezing from vasomotor rhinitis patients. Our study is a collective analysis of retrospective and prospective cohort studies done separately in diosmin hesperidin combination in treatment of vasomotor rhinitis versus intranasal steroids in treatment of it. The data analysed and results showed statistically significant difference between two modalities of treatment between disomin hesperidin combination (flavinoids) which showing efficacy 86.96% and intranasal steroids showing efficacy 72.5%. Conclusion: The available data favors the efficacy of usage of Diosmin and Hesperidin combination (Daflon servier) either as a monotherapy or combination with intranasal steroids for cases of Vasomotor Rhinitis, further randomized controlled studies must be conducted in the future.