STUDY THE EFFECT OF TRETMENT OF HELICOBACTER PYLORI INFECTION ON PLASMA FIBRINOGEN LEVEL IN PATIENTS WITH ISCHEMIC HEART DISEASE

Abstract

Recent studies have suggested that chronic infections with H. pylori may be associated with the risk of ischaemic heart disease. These chronic infections are accompanied by a persistant inflammatory response which may contribute . to the risk of coronary heart disease by increasing the concentration of plasma

fibrinogen as a predictor of coronary heart disease. • I I I Our aim was to evaluate a possible relation between H. pylori infection, I I I plasma fibrinogen and IHD. I I This study . was conducted on 37 patients with IHD, 2 patients• were• I I I excluded from the study due to failure of eradication of H.pylori, so the study I l was completed on 35 IHD patients (21 males, 14 females) and 10 healthy

subjects as a control group (§ males, 4 females):

• H. pylori was tested in all the studied groups using specific lgG antibodies by ELISA. • Fibrinogen level (gm/L) was detected in all the studied groups using the

Clauss method and in the seropositive patients only after the eradication of

H, Pylori.

• . Eradication of .H. pylori in seropositive patients by a new combination treatment to be to taken for only one week, consisting of omeperazole (20 mg) once a day combined with clarithromycin (500 mg) twice daily and tinidazol (500 mg) twice daily.. • After 3 months from the start of treatment, H. pylori IgG was estimated in

the treated patients to confirm eradication of the organism. Patients with failure of eradication were excluded from the study (2 cases).

The results of our study showed that positive family history was significantly higher in]HD patients than control (P<0.05).