Hereditary Thrombophilia in Recurrent IVF Failure

Abstract

he predominant part of IVF cycles results in embryo transfer, but only about one third of all cycles reach clinically achieved pregnancy. This is evidence that most embryos failed in an early stage of pregnancy achievement. Recurrent implantation failure after IVF procedures emphasize the clinical importance of this crucial step in assisted reproductive technology. Repeated unsuccessful IVF attempts force efforts to investigate the firm mechanism of the implantation and to find approach to increase pregnancy outcome success. Plenty of factors have been recognized to affect either success, or failure rate of IVF embryo transfer. Hereditary thrombophilia may pay a role in repeated ivf failure through alteration in endometrium blood vessels leading to implantation failure. The aim of this study is to evaluate the effect of congenital thrombophilia on embryo implantation in an IVF cycle as to make proper management leading to increase IVF success rate. The study enrolled 30 consecutive patients with recurrent IVF failure. They were recruited from sunrise fertility center during the period between 2017 and 2018 all patients aged from 20-40 years old. All patients were negative for prothrombin