Development of Multifunctional Drug Vehicles Based on Functionalized Multi-Walled Carbon Nanotubes

Abstract

Developing a new drug delivery system tends to trigger the growing of tick’s infestation in cattle as it leads to inflammation of the skin and continuous rubbing which lead to skin injury and cause economic problems. This study aims at preparation and characterization of a novel drug delivery system based on functionalized MWCNTs with TEOS using sol-gel technique, in the presence of ABZ, IVM and Cav and/or β-CD which were used as a drug models. The prepared materials were characterized using FTIR, TEM, particle size distribution analysis using DLS technique and TGA. In vitro kinetic release study of the immobilized ABZ, IVM and Cav were carried out in PBS at pH 2.5 at 37°C using the different mathematical models (zero order, first order, hixson- Crowell and higuchi). Moreover, in vitro cytotoxic effect on the normal fibroblast cell line (BHK- 21) using SRB assay, was also investigated. The results indicated that FTIR, TGA, TEM and particle size analysis of the prepared materials showed the successful immobilization of ABZ, IVM and Cav onto the functionalized MWCNTs through covalent bonds with a particle size range of around 495, 395 and 475 nm in the case of ABZ, IVM and Cav respectively. The cumulative released resulted in a biphasic