“The Antimicrobial Activity and Clinical Performance of Chitosan-modified Glass Ionomer: A Randomized Clinical Trial”

Abstract

This in-vivo study was designed to assess the antibacterial effect of different GIC formulations and their clinical performance over a nine-month period. GIC was modified by CHX, CS, and TiO2 forming three groups divided randomly by the type of restoration: The selected teeth were divided into groups randomly according to the type of restoration: • Group CS: Glass ionomer cement liquid was mixed with chitosan hydrogel. • Group CTI: In which CS hydrogel was added to GIC liquid and TiO2 nanoparticles powder was mixed with GIC powder. • Group CHX: Positive control group where the glass ionomer powder was mixed with chlorhexidine diacetate powder.

Thirty-nine restorations in primary molars were placed for 20 children, the teeth did not have any pathology other than an occlusal caries D2 (ADA CCS) that did not have any signs or symptoms. the caries was removed from all the walls, then only soft caries was removed from the floor, a dentine sample was taken for the baseline levels of bacteria and then different formulations of GIC were placed, then the WBFS was used to evaluate the pain produced by the procedure.