Assessment of Calprotectin in blood and tissue of Acne Vulgaris patients of different clinical severities

Abstract

cne vulgaris is a multifactorial inflammatory skin disease of the pilosebaceous unit with complex pathogenesis (Bhat, 2017). Calprotectin is a heterodimer of two calcium-binding proteins S100A8 and S100A9, which are members of the S100 protein family, and which play a role in various inflammatory processes, it is mainly present in the cytoplasm of neutrophils and expressed on the membrane of monocytes (Striz and Trebichavský, 2004; De Ponti, 2015). The aim of this work was to measure levels of Calprotectin in plasma and tissue of AV patients with different clinical severities, and compares it with healthy controls, in order to further understand the role of Calprotectin in the etiopathogenesis of AV and correlating it with disease severity. Our study included 28 subjects who have AV, divided into four groups according to Global Acne Grading System: the first group included 7 patients with mild acne, the second group included 7 patients with moderate acne, the third group included 7 patients with severe acne, and the fourth group included 7 patients with very severe AV. In addition to a control group which included 28 apparently healthy individuals. 3ml blood sample was taken from each patient as well as Two tissue biopsies (size = 2.5 mm) one from papule