Study for the Role of Resistin in detecting Insulin Resistance and their impact on response to direct acting antiviral in chronic viral hepatitis C patients

Abstract

It's well-known that Hepatitis C virus infection is considered a systemic disease, and among extra-hepatic manifestations, insulin resistance and diabetes are reported to be associated with high frequency to the infection.

Experimental & clinical evidences demonstrated that HCV core protein plays a pathogenic role in the development of insulin resistance. It has been reported that the risk of developing type 2 diabetes mellitus is 11 times higher in patients with HCV infection, in which there is a direct correlation between viremia and IR levels and the development of type 2 diabetes (Adinolfi et al., 2016)

The aim of this study is to evaluate the role of Resistin in detecting Insulin Resistance and their impact on response to direct acting antiviral in chronic hepatitis C patients.

This prospective Cohort clinical study was conducted on40 Egyptian patients who were ≥18years of age having chronic viral hepatitis C and 10 healthy control, recruited from Ain shams university hospital center for treatment of viral hepatitis. Our Results showed and compared the three study groups as regards fasting insulin level, HOMA-IR and Serum Resistin Level pre-treatment, which shows statistical significance being higher in naïve and relapser in comparison to control with P-value <0.001. Also comparison between the two groups as regards FBS, Fasting Insulin Level, HOMA-IR equation and Serum Resistin Level pre-treatment and post-treatment, in the Naïve Group with which shows statistical significance being higher in naïve and relapser pre-treatment with P-value <0.001 in both groups.