A STUDY ON THE FORMULATION AND AVAILABILITY OF MECLOZINE HCL FROM CERTAIN PHARMACEUTICAL DOSAGE FORMS

Abstract

The present investigation was initiated with an ultimate goal of promoting the solubility and dissolution rate of meclozine HCI. Meclozine HCl is an antihistaminic drug that is used mainly in the treatment of motion sickness, nausea, vomiting associated with pregnancy. It is used also to relief mild allergic conditions. Meclozine HCl is slightly water soluble, a property that limits its dissolution prior to its absorption and, hence could limit its bioavailability upon administration. In the present investigation, some techniques were applied to improve the solubility and dissolution rate of meclozine HCl, viz.: solid dispersion with certain water-soluble carriers, cyclodextrin complexation and loading onto surface of certain adsorbents. Furthermore, the physicochemical characteristics of the prepared systems were studied as well as the release of meclozine HCl from those systems. Additionally, meclozine HCI was formulated insuppositories dosage forms and some of the prepared systems were chosen and formulated in tablet dosage form. As an integral part of the work, attempts were made to discuss the main mechanism(s) responsible for dissolution rate improvement of the drug and to shed some light on the mechanism of interaction between the drug and some macromolecules in solid and liquid states.