Effect of Apelin on hepatic dysfunction in a rat model of heart failure

Abstract

The present study displayed the effect of pretreatment of apelin on liver dysfunctionsin isoprenaline-induced heart failure rat model. This study was performed on 39 adult female Wistar rats, weighing 170 -200 grams at the start of the study that were assigned randomly into 3 groups: Group 1:Control group (n=13): This group of rats was subjected to daily intraperitoneal injection of saline for 2 weeks. Group 2:Isoprenaline induced heart failure group (Iso group) (n=13): This group of rats was subjected to daily intraperitoneal injection of saline for 2 weeks. In the last 2 days of experimentalprotocol,they were subcutaneouslyinjectedwith isoprenaline in a dose of 100 mg /kgtwice with 24 hours apart between the 2 doses (Shahzad et al., 2019). Group 3:Apelin group (n=13): This group of rats was subjected to daily intraperitoneal injection of apelin-13 at a dose of 15 µg/kg/day (Xu et al., 2017) for 2 weeks. In the last 2 days of experimentalprotocol,they were