Correlation Between Ultrasound Findings And Molecular Subtypes Of Breast Cancer

Abstract

Breast cancer is the most common malignant tumor and the major cause of death among women worldwide. Molecular subtyping of breast cancer is important to individualize its management, to understand prognosis of disease and avoid overtreatment. Although the histopathological diagnosis is the gold standard for distinguishing the molecular subtypes of breast cancer, it is invasive and might cause physical and psychological discomfort in patients. Accordingly, the development of non-invasive method for the diagnosis of breast cancer had been increased in the past decade. U/S with its high level of safety and low cost, was becoming the preferred method for physicians and patients. Reports had indicated that improvements in U/S technologies might make it possible to differentiate malignant solid breast masses highly sensitively from benign once based on their different U/S criteria. The current study was conducted on females with breast cancer who presented to the Radiology Department, Ain-shams Faculty of Medicine, Breast unite of General Surgery, Oncology & Nuclear Medicine Department Breast. U/S guided biopsy was scheduled for patients with suspicious breast lesions. Correlation between the u/s features and the different molecular subtypes was finally done. The present study comprised 40 patients with breast cancers. When analyzing the main four breast cancer subtypes in the current work we found that the rates of LA 34%, LB 40%, HER2 15%, and TNBC 11%.