Effect of Magnesium Oxide Irrigating Solution on Human Cells’ Viability And Extracellular PH Change

Abstract

Complete debridement of the root-canal system with the use of appropriate irrigants and medications reduces the number of microorganisms and increases chances for successful root-canal therapy. Using toxic irrigants can cause not only complications during the course of root-canal treatment but may interfere with the repair process as well, especially during REPs, where conservation of stem cells is important for pulp regeneration. Therefore, in choosing irrigants or medications during root-canal treatment, biocompatibility should be a major consideration. An ideal root-canal irrigant should have strong antibacterial properties and minimal cytotoxic effects on the host tissues.76 Local and even systemic pH fluctuations can frequently occur under pathological conditions. Dental pulp is exposed to changes in extracellular pH under various circumstances.6 The use of metal oxide nanoparticles has recently paid lots of attention, mainly due to their promising antimicrobial activity and their biocompatibility with cells. Magnesium oxide nanoparticle (nMgO) is a light metal based antimicrobial nanoparticle that thought to be biocompatible with cells and can be used in REPs.