Toxic Effects Of Triclabendazole On Liver And Kidney Functions
Ghada Mahmoud Gomaa Ibrahim;
Abstract
Tricalbendazole (TCBZ) is one of the recent benzimidazoles active against immature and mature F. hepatica and F. gigantica. The drug is commonly used in veterinary medicine.
The present • work was designed to study the effect of TCBZ at high doses on the biochemical parameters including liver and kidney function tests, blood picture and histology of some body organs (liver, spleen, kidney, heart, lung, muscles and brain).
In this work, 90 albino rats are divided into 3 main groups, each of 30 rats.
The frist group was kept as a control, second group was given 1 /40 LDso (200 mg/kg b.w.) dose, third one was given 1/20 LDso(400 mg/kg b.w.) dose. Each group was divided into 6 subgroups, each of 5 rats which was administered the drug orally twice weekly using stomach tube.
Each week one subgroup from each main group was sacrificied.
The obtained results are summarized as follow:
1- Effect of TCBZ (200 and 400 mg/kg b.w. doses twice weekly) on liver and kidney function tests.
Blood samples were obtained weekly from control and treated subgroups intended to be sacrificed and serum was. prepared to measure the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), alkaline phosphatase (AP), total protein, albumin, globulins, total bilirubin, direct bilirubin, glucose, cholestrol, urea, uric acid and creatinine.
The study revealed that rats treated with 200 mg/kg b.w. twice weekly of
drug showed a significant increase in the activity of all previous parameters. except glucose which showed a significant decrease.
The present • work was designed to study the effect of TCBZ at high doses on the biochemical parameters including liver and kidney function tests, blood picture and histology of some body organs (liver, spleen, kidney, heart, lung, muscles and brain).
In this work, 90 albino rats are divided into 3 main groups, each of 30 rats.
The frist group was kept as a control, second group was given 1 /40 LDso (200 mg/kg b.w.) dose, third one was given 1/20 LDso(400 mg/kg b.w.) dose. Each group was divided into 6 subgroups, each of 5 rats which was administered the drug orally twice weekly using stomach tube.
Each week one subgroup from each main group was sacrificied.
The obtained results are summarized as follow:
1- Effect of TCBZ (200 and 400 mg/kg b.w. doses twice weekly) on liver and kidney function tests.
Blood samples were obtained weekly from control and treated subgroups intended to be sacrificed and serum was. prepared to measure the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), alkaline phosphatase (AP), total protein, albumin, globulins, total bilirubin, direct bilirubin, glucose, cholestrol, urea, uric acid and creatinine.
The study revealed that rats treated with 200 mg/kg b.w. twice weekly of
drug showed a significant increase in the activity of all previous parameters. except glucose which showed a significant decrease.
Other data
| Title | Toxic Effects Of Triclabendazole On Liver And Kidney Functions | Other Titles | التأثيرات السمية للتراى كلا بندازول على وظائف الكبد والكلى | Authors | Ghada Mahmoud Gomaa Ibrahim | Issue Date | 2000 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B15303.pdf | 1.04 MB | Adobe PDF | View/Open |
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