COLONIC MOTILITY DYSFUNCTION AMONG TYPE 2 DIABETIC PATIENTS

Abstract

Diabetes mellitus affects a large number of people throughout the world. More than 120 million people in the world suffer from diabetes mellitus and it is predicted to be more than double reaching 300 million by the year 2025. In diabetic patients large bowel and rectal atony as well as megacolon has been described. The resultant symptom is constipation, which has been claimed to be the most common manifestation of autonomic neuropathy affecting the gastrointestinal tract. Constipation was reported to occur in 22.1 % of type 2 diabetic patients.

The exact etiology and pathophysiological basis for chronic constipation in diabetics remains obscure. The aim of this study is to evaluate the colon function and rectal defecatory mechanism among type 2 diabetic patieuts and to correlate the presence of constipation with the existence of other complications as nephropathy, retinopathy and neuropathy. This study was conducted upon:

Twenty patients of type 2 diabetes mellitus with constipation. Five normal, non diabetic subjects with constipation as controls. All patients and normal subjects were subjected to the following: I- Thorough clinical examination.

2- Routine laboratory tests.

3- Glycosylated Haemoglobin.

4- Micro-Albuminurea.

5- Abdominal ullrasongraphy