ASSESSMENT OF BRAIN ATROPHY IN MULTIPLE SCLEROSIS PATIENTS QUANTITATIVE MAGNETIC RESONANCE STUDY AND PSYCHOMETRIC EVALUATION

Abstract

This study was carried out on 30 Egyptian patients diagnosed as having clinically definite multiple sclerosis. They were 16 male and 14 female patients. Their age ranged between 18-39 years with mean age of 28.67 ± 6.3 years. Thirty normal subjects with their age and sex matched with patient group were included as a control group. The aim of this study is to assess brain and spinal cord atrophy in MS patients and its relation to clinical disability and psychometric perfonnance. Patients in this study were subjected to full clinical neurological, clinical disability, clinical neuropsychological and radiological assessment. I. Clinical results showed that: a. The more the duration of illness the more significantly the grade of disability secondary to the disease. b. Patients with secondary progressive MS had significantly a greater disease disability than other types (RR MS and PP MS).