Different Therapeutic Modalities of Delayed Complication of Central Venous Catheter among Critically Ill Children: A Systematic Review and Meta-analysis

Abstract

Central venous catheter is commonly performed in care of the pediatric patient. There are a multitude of complications that are associated with their placement. Complications can present in an immediate or delayed fashion. Significant morbidity and mortality can result from complications related to central venous access. We aimed at performing an updated comprehensive systematic review and meta-analysis of the published randomized controlled trials and observational studies on demonstrating the role of unfractionated heparin and low molecular weight heparin in prevention catheter flow thrombotic complications in children with central venous catheter. In addition to the role of taurlodine lock solutions in prevention central line associated blood stream infection in those children with central venous catheter. Methods: The search conducted in four electronic databases PubMed, Google Scholar, Elsevier’s thrombosis journal, and the Cochrane Central Register for Controlled Trials (CENTRAL) for articles published in peer-reviewed journals from 2000 to December 2018. Furthermore, the titles and abstracts of the studies resulted from the search were screened for the inclusion in the systematic review and the meta-analysis based on the inclusion and exclusion criteria. Included observational studies, and randomized controlled trials are assessed for clinical, laboratory, and imaging characteristics of CVC thrombotic complications