SYNTHESIS OF CERTAIN PYRANOQUINOLONES AS POTENTIAL ANTIMICROBIAL AGENTS
FADI MOHSEN AWADALLAH;
Abstract
The discovery of nalidixic acid (NAL) as an antibacterial agent for urinary tract infections in 1960s has opened an ever growing field of antimicrobial agents; namely the 4-quinolones. The present investigation deals with the preparation of pyranoquinolone compounds as analogs of NAL.
The thesis consists of the following parts:
1) Introduction:
In this section a brief literature review of the different methods of preparation and the biological activities of quinolones, benzopyrones and pyranoquinolines is presented with a special emphasis on their antibacterial activities.
2) Aim of the work:
In this part the rationale upon which the newly synthesized
compounds were designed is presented.
3) Discussion:
It deals with the discussion of the experimental methods
adopted for the synthesis of the chosen compounds and the confirmation of their structures by different chemical and spectral analyses. Schemes 1 and 2 illustrate the synthetic pathways followed in the preparation of the target compounds.
4) Experimental:
In th is part, the practical procedures used for the synthesis
of seventy-four new compounds and six known intermediates are cited, in addition to their spectral and microanalytical data
The thesis consists of the following parts:
1) Introduction:
In this section a brief literature review of the different methods of preparation and the biological activities of quinolones, benzopyrones and pyranoquinolines is presented with a special emphasis on their antibacterial activities.
2) Aim of the work:
In this part the rationale upon which the newly synthesized
compounds were designed is presented.
3) Discussion:
It deals with the discussion of the experimental methods
adopted for the synthesis of the chosen compounds and the confirmation of their structures by different chemical and spectral analyses. Schemes 1 and 2 illustrate the synthetic pathways followed in the preparation of the target compounds.
4) Experimental:
In th is part, the practical procedures used for the synthesis
of seventy-four new compounds and six known intermediates are cited, in addition to their spectral and microanalytical data
Other data
| Title | SYNTHESIS OF CERTAIN PYRANOQUINOLONES AS POTENTIAL ANTIMICROBIAL AGENTS | Other Titles | تشييد بعض مركبات بيرانوكينولون كمواد مضادة للميكروبات | Authors | FADI MOHSEN AWADALLAH | Issue Date | 2000 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B17203.pdf | 2.57 MB | Adobe PDF | View/Open |
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