Effect of Aloin on Mitotic Regulators in Human Breast Cancer Cell Lines

Abstract

Breast cancer is a complex disease encompassing multipletumor entities, each characterized by distinct morphology, behavior and clinical implications. Triple negative breast cancer (TNBC) is the most lethal subtype of breast cancer owing to high heterogeneity, aggressive nature and lack of treatment options. Although, the chemotherapy remains the standard of care for TNBC treatment, patients frequently develop resistance. Chemotherapy resistance presents a significant hurdle for successful cancer treatment, especially in the metastatic setting, where it accounts for 90% of therapy failure. Mitosis is a critical and highly orchestrated event in the cell cycle. Errors in the choreography of this event may lead to uncontrolled proliferation, aneuploidy and genetic instability culminating in cancer development. Aurora kinases play a prominent role as essential regulators of the mitotic spindle and have been attributed to a wide range of functions in the mitotic control, including regulation of spindle assembly checkpoint pathway, function of centrosomes and cytoskeleton, and cytokinesis. Overexpression of aurora kinases is generally detected in a wide variety of human cancers.