Effect of Argel Herbs (Solenostemma argel) on-induced Liver Cirrhosis by Carbon Tetra Chloride in Rats

Abstract

Agral (Solenostemma argel) is a traditional edible herb that is commonly used in folkloric medicine for the treatment of rheumatic pain, inflammation, hyperlipidemia, hyperglycemia and antimicrobial agent due to its rich in bioactive component which act as antioxidants. Therefore, chemical composition and antioxidants contents and its activity were analyzed.

Forty-eight male albino rats were used in biological experiments. Rats were fed the basal diet for two weeks prior to conducting the experiment. Initially, rats divided into six main groups and fed on rations for 42 days as follows: the negative control group (the first group) was fed on the basal diet. Forty male albino rats were fed on a basic diet and stimulated with carbon tetra chloride (CCl4( in paraffin oil (50% v/v, 2 mL/Kg) twice a week by subcutaneous injection to induce chronic liver damage, then divided into 5 groups numbered from group 2 to group 6. Rats of the positive control group were fed basal diet until the final experiment. Group 3 and 4 rats were treated with dry leaves (0.5g and1.0g, respectively) of Argel. Also, group 5 and 6 were fed on 50 ppm and 100 ppm of hydroethanolic extracts orally, respectively.