Utility of p-acetamidobenzoyl prop-2-enoic acid in the synthesis of new α-amino acids and using them as building blocks in heterocyclic synthesis

Abstract

THE PRESENT work deals with the generation and synthesis of different unnatural amino acid derivatives via treatment of 3-(4-acetamidobenzoyl)-prop-2-enoic acid with 5-aryl-2-amino 1, 3, 4 thiadiazole, 3, 5-dimethyl pyrazoie and barbituric acid to afford the product of conjugate addition acids (1) respectively. Additionally, the adduct 1 are used as key starting materials to synthesize some heterocycles include pyridazene, furanone and oxazine derivatives. The antimicrobial screening of some of the synthesized compounds was done using the agar diffusion assay.