Design, synthesis, molecular dockingstudy andtoxicological evaluation potential of novel spiro and fused heterocyclic derivatives against agricultural insect pests

Abstract

Reactions of 4'-(2-oxo-3-(thiophen-2-ylmethylene) furan-5-yl) acetanilide with amines, carbon nucleophiles and isatin, under various conditions provided a diversification of spiro-, fused- and heteocyclic deivatives. The constructions of the novelcomposites were distinguished by spectral data and elemental analysis. larvicidal activities of the synthesized compounds were examined against Plutella xylostella and Helicoverpa armigera larvae in vitro. The molecular docking simulationresults towards acetylcholinesterase of Drosophila Melanogaster demonstrated the role of the novel compounds as prominent larvicides.