Synthesis, DFT and antimicrobial studies of 5,6,7,8- Tetrachloro phthalazin-1-ol and 2,3-benzoxazin-1(2h)-one derivatives
Rizk, Sameh Ahmed; Youssef, Mohamed Fathy; Mubarak, Ahmed M.;
Abstract
2-Aroylbenzoic acidwas allowed to react with hydrazine hydrate, hydroxylamine and methylhydrazine to afford the corresponding 5,6,7,8-tetrachloro-4-aryl-phthalazin-1-one. The antimicrobial effect of the phthalazin-1-one in the water of the swimming pool and river can be discussed. DFT based on quantum chemical computational of the new compounds were synthesized with the objective of studying their antimicrobial activity. The newly synthesized compounds were characterized on the basis of theirspectral (1H-NMR, Mass spectrum, IR and Elementary analysis.
Other data
| Title | Synthesis, DFT and antimicrobial studies of 5,6,7,8- Tetrachloro phthalazin-1-ol and 2,3-benzoxazin-1(2h)-one derivatives | Authors | Rizk, Sameh Ahmed ; Youssef, Mohamed Fathy; Mubarak, Ahmed M. | Keywords | 2 | 2-Methyl-phthalazinone;3-Benzoxazin-1-one;DFT Antimicrobial reagents;Phthalazin-1-ol | Issue Date | 1-May-2020 | Journal | Egyptian Journal of Chemistry | Volume | 63 | Issue | 5 | Start page | 1767 | End page | 1777 | ISSN | 04492285 | DOI | 10.21608/ejchem.2019.16936.2036 | Scopus ID | 2-s2.0-85089886801 |
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