1.4-AryIation of β-(4-acetylaminobenzoyl)acrylic acid with activated aromatic hydrocarbons under friedel-crafts conditions and some Studies with the Products
Rizk, Sameh Ahmed; El Hashash, M. A.; Aburzeza, M. M.;
Abstract
THE BEHAVIUOR of 3-(4-acetylaminobenzoyl) prop-2-enoic acid 1 with m-xylene and\or p-xylene under Friedel-Crafts reaction conditions yielded 2- (2, 4-Dimethyl and/or 2, 5-dimethyl) phenyl-3-(4-acetylaminobenzoyl)propanoic acids (2a,b) and thia Micheal of acid 1 afforded 2-phenyl sulfanyl-3-(4-acetylamino benzoyl propanoic acid (3). Interaction of acids 2,3 with N2H4, AC2O, NH2OH.HCl and PhNHNH2, yielded pyridazinone 4, Furanone 5 1, 2oxazine 6 and 2-phenyl pyridazinone derivatives, respectively. Treatment of pyridazinone 4 with different interesting alkyl halides afforded the pyridazine derivatives 8.
Other data
| Title | 1.4-AryIation of β-(4-acetylaminobenzoyl)acrylic acid with activated aromatic hydrocarbons under friedel-crafts conditions and some Studies with the Products | Authors | Rizk, Sameh Ahmed ; El Hashash, M. A.; Aburzeza, M. M. | Keywords | 3-Aroyl prop-2-enoic acid;Oxazinone and alkyl pyridazine;Pyridazinone furanone | Issue Date | 1-Jan-2011 | Journal | Egyptian Journal of Chemistry | ISSN | 04492285 | Scopus ID | 2-s2.0-84875594048 |
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