One-pot Synthesis of Novel Spirooxindoles as Antibacterial and Antioxidant Agents

Abstract

The regioselective spiroindoline derivatives were afforded via multi-componant reaction. Its process was one of the green chemistry (simplicity, mild conditions, and atomic economy). The electron repelling and attracting groups affected on reactivity of the azomethine ylides (increase EHOMO value). All compound structures were confirmed by spectroscopic data and elemental analysis. The antibacterial and antioxidant activities for these synthesized compounds could be investigated; the highly antioxidant activity was observed with compounds, which proved to possess high HOMO values, and the highly antibacterial activity was observed against S. aureus, B. cereus, S. marcesens, and P. mirabilis, which proved to possess low HOMO values.