New 1,3,4-Thiadiazole Derivatives: Synthesis, Characterization, and Antimicrobial Activity

Abstract

In the present study, 2,5-bis(mercapto-acetichydrazide)-1,3,4-thiadiazole (1) was utilized by different reagents, namely, ethoxymethylene malononitrile, ethoxymethylene ethyl cyanoacetate, triethyl orthoformate, phenyl isothiocyanate, carbon disulfide, isatin, acetophenone, cyclohexanone, different aldehydes, and different anhydrides, to yield a new series of 2,5-disubstituted-1,3,4-thiadiazoles 2–18. The chemical structure of these products was characterized by the spectral data IR, 1 H-NMR, 13 C-NMR, MS, and elemental analysis. All the synthesized compounds were screened for their antibacterial activity.