Role of Herbalism in Systemic Lupus Erythematosus Treatment

Abstract

The well-known inflammatory and autoimmune condition known as systemic lupus erythematosus (SLE) causes symptoms in the kidneys, the skin, the brain, and the heart. It can also cause complications that affect several organs. The diversity in organ involvement and heterogeneous conditions of patients led to the complicated management of SLE. Increasingly, there is evidence highlighting the importance of phytochemicals in both dietary and non-dietary contexts in the management of SLE without side effects. Herein, we discuss the role of different plant extracts with their metabolites and their modes of action against SLE updated to 2023, in addition to the incorporation of herbal formulas in the management of the SLE. The present work is an overview of different plant extracts and their secondary metabolites with significant anti-inflammatory, antioxidant, and immunomodulation in SLE. The current chapter focuses on the various targets, mechanisms, and pathways of natural products that manage SLE. Based on the current work, it can be inferred that natural products show potential as effective agents in the medical care of SLE.