Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazole-2(3H)-thione and Azidomethanone Derivatives Based on Quinoline 4-carbohydrazide Derivatives

Abstract

A new series compounds of quinoline derivatives were synthesized by reaction of 3-(carboxymethyl)-2- arylquinoline-4-carboxylic acids 1a–c with different nucleophiles. The structures of the new compounds were elucidated on the basis of FTIR, 1 H-NMR, 13C-NMR spectral data, GC/MS, and chemical analysis. In vestigation of antimicrobial activity of all new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration count against four pathogenic bacteria and two pathogenic fungi. Most of the new compounds were significantly active against bacteria and fungi.