Design and evaluation of a novel chitosan-based system for colon-specific drug delivery
Kandile, Nadia; Iman Kavianinia; David R. Harding; Paul G. Plieger; Nicholas J. Cave; Gayathri Gopakumar; Magdalena Dunowska;
Abstract
Tritrichomonas foetus is a flagellated protozoan parasite that colonizes the feline colon causing colitis and
chronic foul smelling diarrhoea. Despite the efficacy of Ronidazole in the treatment of T. foetus, Ronidazole
has been reported to cause neurotoxicity in some cats due to rapid absorption in the small intestine. A
novel amphoteric derivative of chitosan was synthesised and characterized. A combination of time, pH,
and an enzyme controlled system was used in a study of a new compression coated tablet for delivery of
Ronidazole to the colon. Axial, radial swelling and erosion of selected tablets were carried out in various
media. The effect of weight ratio, enzyme and pH on in vitro drug release profile was investigated. The
results show that less than 2% of the drug was released in the physiological environment of the stomach
and small intestine.
chronic foul smelling diarrhoea. Despite the efficacy of Ronidazole in the treatment of T. foetus, Ronidazole
has been reported to cause neurotoxicity in some cats due to rapid absorption in the small intestine. A
novel amphoteric derivative of chitosan was synthesised and characterized. A combination of time, pH,
and an enzyme controlled system was used in a study of a new compression coated tablet for delivery of
Ronidazole to the colon. Axial, radial swelling and erosion of selected tablets were carried out in various
media. The effect of weight ratio, enzyme and pH on in vitro drug release profile was investigated. The
results show that less than 2% of the drug was released in the physiological environment of the stomach
and small intestine.
Other data
| Title | Design and evaluation of a novel chitosan-based system for colon-specific drug delivery | Authors | Kandile, Nadia ; Iman Kavianinia; David R. Harding; Paul G. Plieger; Nicholas J. Cave; Gayathri Gopakumar; Magdalena Dunowska | Keywords | Amphoteric chitosan;Tablet;Colonic drug delivery;Ronidazole | Issue Date | 11-Jan-2016 | Publisher | Elsevier B.V | Journal | International Journal of Biological Macromolecules | Volume | 85 | Start page | 539 | End page | 546 | DOI | http://dx.doi.org/10.1016/j.ijbiomac.2016.01.003 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.