Lactoferrin ameliorates carfilzomib-induced renal and pulmonary deficits: Insights to the inflammasome NLRP3/NF-κB and PI3K/Akt/GSK-3β/MAPK axes
Habib, Christine N; Ali, Alaa E; Anber, Nahla H; George, Mina Y.;
Abstract
Carfilzomib, an irreversible proteasome inhibitor, has been increasingly used to treat multiple myeloma worldwide. However, case studies showed its treatment has been associated with cardiac, renal, and pulmonary deleterious effects. Lactoferrin is an iron-binding glycoprotein present in milk. It is a multifunctional protein with antimicrobial activity, antitumor, antioxidant, and anti-inflammatory effects. Thus, this study aimed to assess the protective effects of lactoferrin against carfilzomib-induced nephrotoxicity and pulmonary toxicity, in addition to identifying the possible underlying molecular mechanisms.
Other data
| Title | Lactoferrin ameliorates carfilzomib-induced renal and pulmonary deficits: Insights to the inflammasome NLRP3/NF-κB and PI3K/Akt/GSK-3β/MAPK axes | Authors | Habib, Christine N; Ali, Alaa E; Anber, Nahla H; George, Mina Y. | Keywords | Carfilzomib;Kidney;Lactoferrin;Lung;NLRP3/NF-κB, PI3K/AKT/GSK-3β/MAPK | Issue Date | 15-Dec-2023 | Journal | Life Sciences | Volume | 335 | ISSN | 00243205 | DOI | 10.1016/j.lfs.2023.122245 | PubMed ID | 37926296 | Scopus ID | 2-s2.0-85178205186 |
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