Application of Savitzky-Golay differentiation filters and Fourier functions to simultaneous determination of cefepime and the co-administered drug, levofloxacin, in spiked human plasma
Abdel-Aziz, Omar; Farouk Abdel Ghany, Maha; Nagi, Reham; Abdel-Fattah, Laila;
Abstract
The present work is concerned with simultaneous determination of cefepime (CEF) and the co-administered drug, levofloxacin (LEV), in spiked human plasma by applying a new approach, Savitzky-Golay differentiation filters, and combined trigonometric Fourier functions to their ratio spectra. The different parameters associated with the calculation of Savitzky-Golay and Fourier coefficients were optimized. The proposed methods were validated and applied for determination of the two drugs in laboratory prepared mixtures and spiked human plasma. The results were statistically compared with reported HPLC methods and were found accurate and precise.
Other data
| Title | Application of Savitzky-Golay differentiation filters and Fourier functions to simultaneous determination of cefepime and the co-administered drug, levofloxacin, in spiked human plasma | Authors | Abdel-Aziz, Omar; Farouk Abdel Ghany, Maha ; Nagi, Reham; Abdel-Fattah, Laila | Keywords | Cefepime;Fourier;Levofloxacin;Plasma;Savitzky-Golay;Spectrophotometry | Issue Date | 15-Mar-2015 | Journal | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Volume | 139 | Start page | 449 | End page | 455 | ISSN | 13861425 | DOI | 10.1016/j.saa.2014.12.046 | PubMed ID | 25576942 | Scopus ID | 2-s2.0-84920647271 |
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