Determination of degradation products from the calcium-channel blocker isradipine
Bartlett, Michael G.; Christopher Spell, J.; Mathis, Pheobe S.; Farouk Abdel Ghany, Maha; El Zeany, Badr E.; Elkawy, Mohammed A.; Stewart, James T.;
Abstract
Mass Spectrometry has been used to determine the identity of a number of degradation products from the bulk drug form of Isradipine (DynaCirc). Liquid chromatography coupled with mass spectrometry (LC/MS) was used to analyze the degraded samples and tentative identifications were made based upon the known reactivity of the molecule, molecular weight measurements and mass spectral fragmentation patterns. Isradipine was found to be stable to heating, acidic and basic conditions, but susceptible to degradation from exposure to UV light and oxidative processes. Copyright (C) 1998 Elsevier Science B.V.
Other data
| Title | Determination of degradation products from the calcium-channel blocker isradipine | Authors | Bartlett, Michael G.; Christopher Spell, J.; Mathis, Pheobe S.; Farouk Abdel Ghany, Maha ; El Zeany, Badr E.; Elkawy, Mohammed A.; Stewart, James T. | Keywords | Degradation;Isradipine;LC/MS;Pharmaceuticals | Issue Date | 1-Nov-1998 | Journal | Journal of Pharmaceutical and Biomedical Analysis | Volume | 18 | Issue | 3 | Start page | 335 | End page | 345 | ISSN | 07317085 | DOI | 10.1016/S0731-7085(98)00047-8 | PubMed ID | 10096828 | Scopus ID | 2-s2.0-0031738534 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.