Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives
Abdel Ghani, Sherif B.; Weaver, Louise; Zidan, Zidan H.; Ali, Hussein; Keevil, C. William; Brown, Richard C.D.;
Abstract
Eleven flavonoid derivatives were synthesised using a modified Baker-Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus. © 2007 Elsevier Ltd. All rights reserved.
Other data
| Title | Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives | Authors | Abdel Ghani, Sherif B.; Weaver, Louise; Zidan, Zidan H.; Ali, Hussein ; Keevil, C. William; Brown, Richard C.D. | Keywords | Antibacterial;Antifungal;Flavonoids | Issue Date | 15-Jan-2008 | Journal | Bioorganic & medicinal chemistry letters | Volume | 18 | Start page | 518 | End page | 533 | ISSN | 0960894X | DOI | 10.1016/j.bmcl.2007.11.081 | PubMed ID | 18068365 | Scopus ID | 2-s2.0-38149062729 |
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