Association between POLG and XRCC1 gene polymorphisms and keratoconus occurrence among Egyptian patients
Awd-Allah, N A; Ismail, S M; Salah El-Dine, M M; Mohamed, Magdy;
Abstract
Keratoconus is a progressive disorder distinguished by thinning of the corneal tissue and bulging forward into a cone-shaped fashion. Yet its etiology, which is multifactorial, despite intensive research remains elusive. Corneal exposure a reactive oxygen species causing oxidative DNA damage has been reported to be associated with KC and therefore suggesting that DNA base excision repair mechanism might lie behind the pathogenesis of the disease.
Other data
| Title | Association between POLG and XRCC1 gene polymorphisms and keratoconus occurrence among Egyptian patients | Authors | Awd-Allah, N A; Ismail, S M; Salah El-Dine, M M; Mohamed, Magdy | Keywords | Base excision repair;Genotipado;Genotyping;Keratoconus;PCR-RFLP;POLG;Queratocono;Reparación de escisión de base;XRCC1 | Issue Date | Sep-2020 | Journal | Archivos de la Sociedad Espanola de Oftalmologia | Volume | 95 | Issue | 9 | Start page | 439 | End page | 446 | ISSN | 03656691 | DOI | 10.1016/j.oftal.2020.03.019 | PubMed ID | 32414513 | Scopus ID | 2-s2.0-85084765257 |
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