Leukemic B cells expression of CD200 and Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1, CD305) in Chronic Lymphocytic Leukemia patients in relation to Treg frequency
Hammad, Reham; Kandeel, Eman Z; Lambert, Claude; Sack, Ulrich; Kujumdshiev, Sandy; Kamhawy, Arwa; Abo-Elkheir, Omaima I; Abd El Hakam, Fatma El-Zahraa; Mashaal, Alya; Zidan, Abdel-Aziz A; Prof. Hamdy, Nadia M.; Mohammed Ramadan Mohammed;
Abstract
Chronic lymphocytic leukemia (CLL) is characterized by a wide range of tumor-induced immune alterations. Regulatory T cells (Treg) play a central role in these immune responses. CD200 and Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1, CD305) are inhibitory markers said to be involved in Treg immune response. We aimed to analyze the expression of CD200 and LAIR-1 on leukemic cells and assess their interactions with the Treg frequency to elucidate their role in the CLL course.
Other data
| Title | Leukemic B cells expression of CD200 and Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1, CD305) in Chronic Lymphocytic Leukemia patients in relation to Treg frequency | Authors | Hammad, Reham; Kandeel, Eman Z; Lambert, Claude; Sack, Ulrich; Kujumdshiev, Sandy; Kamhawy, Arwa; Abo-Elkheir, Omaima I; Abd El Hakam, Fatma El-Zahraa; Mashaal, Alya; Zidan, Abdel-Aziz A; Prof. Hamdy, Nadia M. ; Mohammed Ramadan Mohammed | Keywords | CD200; CLL; Chronic Lymphocytic Leukemia; FoxP3; LAIR-1; Leukemic B cells; Treg; in silico | Issue Date | Nov-2024 | Journal | Pathology, research and practice | ISSN | 03440338 | DOI | 10.1016/j.prp.2024.155669 | PubMed ID | 39471525 | Scopus ID | 2-s2.0-85208772543 |
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